.restriction-mechanism-entry {
    margin-top: 1.35rem;
}

.restriction-mechanism-trigger {
    display: flex;
    width: 100%;
    min-height: 3.4rem;
    align-items: center;
    justify-content: space-between;
    gap: 1rem;
    padding: 0.85rem 1rem;
    border: 1px solid rgba(21, 25, 43, 0.14);
    border-radius: 0.85rem;
    background: #fff;
    box-shadow: 0 0.35rem 1rem rgba(21, 25, 43, 0.06);
    color: var(--brand-dark);
    cursor: pointer;
    font: inherit;
    font-size: 0.9rem;
    font-weight: 750;
    text-align: left;
    transition-property: border-color, box-shadow, color, scale;
    transition-duration: 150ms;
}

.restriction-mechanism-trigger svg,
.rm-dialog-close svg {
    width: 1.25rem;
    height: 1.25rem;
    flex: 0 0 auto;
    fill: none;
    stroke: currentColor;
    stroke-linecap: round;
    stroke-linejoin: round;
    stroke-width: 2;
}

.rm-trigger-copy {
    display: grid;
    gap: 0.12rem;
}

.rm-trigger-copy strong {
    font-size: 0.9rem;
    line-height: 1.2;
}

.rm-trigger-copy small {
    color: var(--text-muted);
    font-size: 0.68rem;
    font-weight: 500;
    line-height: 1.3;
}

.restriction-mechanism-trigger:hover,
.restriction-mechanism-trigger:focus-visible {
    border-color: var(--magenta);
    box-shadow: 0 0.45rem 1.2rem rgba(236, 0, 140, 0.1);
    color: var(--magenta);
    outline: none;
}

.restriction-mechanism-trigger:focus-visible {
    box-shadow: 0 0 0 3px rgba(236, 0, 140, 0.14), 0 0.45rem 1.2rem rgba(236, 0, 140, 0.1);
}

.restriction-mechanism-trigger:active { scale: 0.96; }

.rm-modal[hidden] { display: none; }

.rm-modal {
    position: fixed;
    z-index: 10000;
    inset: 0;
    display: grid;
    padding: 1rem;
    place-items: center;
}

.rm-modal-backdrop {
    position: absolute;
    inset: 0;
    background: rgba(14, 17, 31, 0.66);
    backdrop-filter: blur(5px);
}

.rm-dialog {
    position: relative;
    z-index: 1;
    width: min(69rem, 100%);
    max-height: calc(100dvh - 2rem);
    padding: 1.85rem 2rem;
    overflow: auto;
    border-radius: 1.25rem;
    background: #fff;
    box-shadow: 0 1.5rem 4rem rgba(8, 10, 22, 0.28);
    color: var(--brand-dark);
    outline: none;
}

.rm-dialog:focus-visible {
    box-shadow: 0 0 0 3px rgba(236, 0, 140, 0.28), 0 1.5rem 4rem rgba(8, 10, 22, 0.28);
}

.rm-dialog-heading {
    padding: 0.2rem 3.2rem 1rem 0.15rem;
}

.rm-dialog-heading span {
    display: block;
    margin-bottom: 0.25rem;
    color: var(--magenta);
    font-size: 0.85rem;
    font-weight: 800;
    letter-spacing: 0.11em;
    text-transform: uppercase;
}

.rm-dialog-heading h2 {
    margin: 0;
    color: var(--brand-dark);
    font-size: clamp(1.75rem, 3vw, 2.65rem);
    line-height: 1.15;
    text-wrap: balance;
    overflow-wrap: anywhere;
    hyphens: auto;
}

.rm-dialog-close {
    position: absolute;
    z-index: 2;
    top: 1rem;
    right: 1rem;
    display: grid;
    width: 2.75rem;
    height: 2.75rem;
    padding: 0;
    border: 0;
    border-radius: 0.75rem;
    background: rgba(21, 25, 43, 0.06);
    color: var(--brand-dark);
    cursor: pointer;
    place-items: center;
    transition-property: background-color, color, scale;
    transition-duration: 150ms;
}

.rm-dialog-close:hover,
.rm-dialog-close:focus-visible {
    background: rgba(236, 0, 140, 0.1);
    color: var(--magenta);
    outline: none;
}

.rm-dialog-close:focus-visible { box-shadow: 0 0 0 3px rgba(236, 0, 140, 0.14); }
.rm-dialog-close:active { scale: 0.96; }
.rm-modal-open { overflow: hidden; }

.restriction-mechanism {
    --rm-cycle: 8s;
    --rm-ease: cubic-bezier(0.2, 0, 0, 1);
    position: relative;
    display: grid;
    width: 100%;
    min-height: 500px;
    margin: 0;
    padding: 1.5rem 1.65rem 1.2rem;
    grid-template-rows: auto minmax(15rem, 1fr) auto auto;
    color: var(--brand-dark);
    background:
        radial-gradient(circle at 50% 48%, rgba(236, 0, 140, 0.08), transparent 36%),
        linear-gradient(145deg, #fff 0%, #faf9fb 100%);
    font-variant-numeric: tabular-nums;
    isolation: isolate;
}

.rm-heading {
    display: flex;
    align-items: baseline;
    justify-content: flex-end;
    gap: 0.8rem;
}

.rm-heading strong {
    color: var(--magenta);
    font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
    font-size: clamp(0.92rem, 1.4vw, 1.18rem);
    letter-spacing: 0.02em;
    white-space: nowrap;
}

.rm-stage {
    position: relative;
    display: grid;
    min-width: 0;
    place-items: center;
}

.rm-dna {
    position: relative;
    z-index: 2;
    display: grid;
    gap: 0.38rem;
    max-width: 100%;
}

.rm-row {
    display: flex;
    min-width: 0;
    align-items: center;
    justify-content: center;
    color: var(--brand-dark);
    font-family: ui-monospace, SFMono-Regular, Menlo, Consolas, monospace;
    font-size: clamp(0.78rem, 1.55vw, 1.12rem);
    font-weight: 800;
    line-height: 1;
    white-space: nowrap;
}

.rm-end {
    width: 1.55rem;
    flex: 0 0 1.55rem;
    color: var(--text-muted);
    font-size: 0.72em;
    text-align: center;
}

.rm-segment {
    position: relative;
    display: inline-flex;
    transform: translateX(0);
    animation-duration: var(--rm-cycle);
    animation-timing-function: var(--rm-ease);
    animation-iteration-count: infinite;
}

.rm-segment-left { animation-name: rm-product-left; }
.rm-segment-right { animation-name: rm-product-right; }

.rm-recognition-site {
    position: relative;
    display: inline-flex;
}

.rm-base {
    position: relative;
    display: grid;
    width: 1.08em;
    aspect-ratio: 0.82;
    place-items: center;
    border-top: 1px solid rgba(21, 25, 43, 0.17);
    border-bottom: 1px solid rgba(21, 25, 43, 0.17);
    background: rgba(255, 255, 255, 0.82);
}

.rm-base.is-recognition {
    border-color: rgba(236, 0, 140, 0.34);
    background: rgba(236, 0, 140, 0.1);
    color: var(--magenta);
}

.rm-base.is-flank {
    color: rgba(21, 25, 43, 0.52);
    font-weight: 650;
}

.rm-base.is-methylated::after {
    position: absolute;
    bottom: calc(100% + 0.15rem);
    left: 50%;
    padding: 0.08rem 0.18rem;
    border-radius: 0.22rem;
    background: var(--magenta);
    color: #fff;
    content: 'CH₃';
    font-family: Arial, sans-serif;
    font-size: 0.52rem;
    font-weight: 800;
    line-height: 1;
    transform: translateX(-50%);
}

.rm-cut-marker {
    position: relative;
    z-index: 5;
    width: 2px;
    height: 1.55rem;
    flex: 0 0 2px;
    border-radius: 2px;
    background: var(--magenta);
    box-shadow: 0 0 0 0.28rem rgba(236, 0, 140, 0.08);
    opacity: 0;
    transform: scaleY(0.25);
    animation: rm-cut-marker var(--rm-cycle) ease-out infinite;
}

.rm-cut-marker::after {
    position: absolute;
    top: 50%;
    left: 50%;
    width: 0.42rem;
    height: 0.42rem;
    border: 2px solid var(--magenta);
    border-top: 0;
    border-left: 0;
    content: '';
    transform: translate(-50%, -50%) rotate(45deg);
}

.rm-enzyme {
    position: absolute;
    z-index: 4;
    top: -0.25rem;
    left: var(--rm-enzyme-x, 50%);
    display: grid;
    width: 5rem;
    height: 4.15rem;
    place-items: center;
    border-radius: 48% 52% 42% 58%;
    background: var(--brand-dark);
    box-shadow: 0 0.7rem 1.4rem rgba(21, 25, 43, 0.16), 0 0 0 0.45rem rgba(21, 25, 43, 0.04);
    color: #fff;
    opacity: 0.52;
    transform: translate(-50%, -1rem) scale(0.78) rotate(-3deg);
    animation: rm-enzyme-bind var(--rm-cycle) var(--rm-ease) infinite;
}

.rm-enzyme span {
    max-width: 4.2rem;
    font-size: 0.62rem;
    font-weight: 800;
    line-height: 1.05;
    text-align: center;
}

.rm-enzyme i {
    position: absolute;
    width: 0.58rem;
    aspect-ratio: 1;
    border: 1.5px solid rgba(255, 255, 255, 0.72);
    border-radius: 50%;
}

.rm-enzyme i:first-of-type { top: 0.72rem; left: 0.82rem; }
.rm-enzyme i:last-of-type { right: 0.82rem; bottom: 0.62rem; border-radius: 35%; }

.rm-cut-flash {
    position: absolute;
    z-index: 3;
    top: 52%;
    left: var(--rm-cut-x, 50%);
    width: 3.8rem;
    aspect-ratio: 1;
    border: 2px solid var(--magenta);
    border-radius: 50%;
    opacity: 0;
    transform: translate(-50%, -50%) scale(0.2);
    animation: rm-cut-flash var(--rm-cycle) ease-out infinite;
}

.restriction-mechanism.is-type-iis {
    --rm-enzyme-x: 32%;
    --rm-cut-x: 67%;
}

.restriction-mechanism.is-dpni-workflow {
    min-height: 420px;
    grid-template-rows: auto minmax(13rem, 1fr) auto auto;
}

.rm-dpni-stage {
    display: grid;
    width: 100%;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 0;
    align-items: stretch;
}

.rm-dpni-track {
    display: grid;
    min-width: 0;
    padding: 0.2rem 1rem;
    grid-template-rows: auto 1fr auto;
    align-items: center;
}

.rm-dpni-track + .rm-dpni-track {
    border-left: 1px solid rgba(21, 25, 43, 0.11);
}

.rm-dpni-track-label {
    display: grid;
    gap: 0.16rem;
    color: var(--brand-dark);
    font-family: Arial, sans-serif;
    line-height: 1.15;
    text-align: center;
}

.rm-dpni-track-label strong {
    font-size: 0.78rem;
    font-weight: 800;
}

.rm-dpni-track-label small {
    color: var(--text-muted);
    font-size: 0.68rem;
    font-weight: 600;
}

.rm-dpni-target {
    position: relative;
    display: grid;
    min-height: 7.5rem;
    place-items: center;
}

.rm-dpni-target .rm-enzyme {
    left: 50%;
}

/* Keep the parked enzyme above both DNA and methylation labels. */
.rm-dpni-track.is-parent-template .rm-dpni-target {
    min-height: 12rem;
}

.rm-dpni-track.is-pcr-product .rm-segment {
    animation: none;
}

.rm-dpni-methylation-key,
.rm-dpni-preserved-key {
    color: var(--text-muted);
    font-family: Arial, sans-serif;
    font-size: 0.64rem;
    font-weight: 700;
    line-height: 1.2;
    text-align: center;
}

.rm-dpni-preserved-key {
    color: rgba(21, 25, 43, 0.76);
}

.rm-recognition-anchor,
.rm-methylation-note {
    position: absolute;
    z-index: 6;
    color: var(--text-muted);
    font-family: Arial, sans-serif;
    font-size: 0.62rem;
    font-weight: 700;
    line-height: 1;
    white-space: nowrap;
}

.rm-recognition-anchor {
    top: calc(100% + 0.65rem);
    left: 50%;
    transform: translateX(-50%);
}

.rm-methylation-note { left: 50%; transform: translateX(-50%); }
.rm-methylation-note { top: 73%; }

.rm-recognition-anchor::before {
    position: absolute;
    bottom: calc(100% + 0.28rem);
    left: 50%;
    width: 1px;
    height: 0.55rem;
    background: rgba(236, 0, 140, 0.4);
    content: '';
}

.rm-summary {
    display: grid;
    margin: 0;
    gap: 0.3rem;
    color: var(--text-muted);
    font-size: 1.08rem;
    line-height: 1.45;
    text-wrap: pretty;
}

.rm-summary strong { color: var(--brand-dark); font-size: 1.1rem; }

.rm-controls {
    display: flex;
    justify-content: flex-end;
    gap: 0.35rem;
    margin-top: 0.52rem;
}

.rm-control {
    min-height: 2.75rem;
    padding: 0.65rem 1rem;
    border: 1px solid rgba(21, 25, 43, 0.14);
    border-radius: 0.65rem;
    background: rgba(255, 255, 255, 0.88);
    color: var(--brand-dark);
    cursor: pointer;
    font: inherit;
    font-size: 0.94rem;
    font-weight: 750;
    transition-property: border-color, background-color, color, scale;
    transition-duration: 150ms;
}

.rm-control:hover,
.rm-control:focus-visible {
    border-color: var(--magenta);
    color: var(--magenta);
    outline: none;
}

.rm-control:focus-visible { box-shadow: 0 0 0 3px rgba(236, 0, 140, 0.14); }
.rm-control:active { scale: 0.96; }

.restriction-mechanism.is-paused *,
.restriction-mechanism.is-paused *::before,
.restriction-mechanism.is-paused *::after {
    animation-play-state: paused !important;
}

.restriction-mechanism.is-restarting *,
.restriction-mechanism.is-restarting *::before,
.restriction-mechanism.is-restarting *::after {
    animation: none !important;
}

@keyframes rm-enzyme-bind {
    0%, 12% { top: 5%; opacity: 0.55; transform: translate(-50%, -1rem) scale(0.78) rotate(-3deg); }
    30%, 58% { top: 36%; opacity: 1; transform: translate(-50%, -50%) scale(1) rotate(2deg); }
    76%, 100% { top: 5%; opacity: 0.55; transform: translate(-50%, -1rem) scale(0.78) rotate(-3deg); }
}

@keyframes rm-cut-marker {
    0%, 43% { opacity: 0; transform: scaleY(0.25); }
    50%, 88% { opacity: 1; transform: scaleY(1); }
    100% { opacity: 0; transform: scaleY(1); }
}

@keyframes rm-cut-flash {
    0%, 44% { opacity: 0; transform: translate(-50%, -50%) scale(0.2); }
    51% { opacity: 0.65; transform: translate(-50%, -50%) scale(1); }
    61%, 100% { opacity: 0; transform: translate(-50%, -50%) scale(1.35); }
}

@keyframes rm-product-left {
    0%, 54% { opacity: 1; transform: translateX(0); }
    68%, 100% { opacity: 1; transform: translateX(-0.65rem); }
}

@keyframes rm-product-right {
    0%, 54% { opacity: 1; transform: translateX(0); }
    68%, 100% { opacity: 1; transform: translateX(0.65rem); }
}

@media (max-width: 720px) {
    .restriction-mechanism-entry { order: 7; }
    .rm-modal { padding: 0.6rem; }
    .rm-dialog {
        max-height: calc(100dvh - 1.2rem);
        padding: 1rem;
        border-radius: 1rem;
    }
    .rm-dialog-heading { padding: 0.15rem 3rem 0.8rem 0; }
    .rm-dialog-close { top: 0.75rem; right: 0.75rem; }
    .restriction-mechanism { min-height: 380px; padding-inline: 0.8rem; }
    .rm-heading { align-items: flex-start; flex-direction: column; gap: 0.2rem; }
    .rm-heading strong { white-space: normal; }
    .rm-row { font-size: clamp(0.56rem, 2.65vw, 0.78rem); }
    .rm-end { width: 1.25rem; flex-basis: 1.25rem; }
    .rm-summary { font-size: 0.84rem; }
    .rm-summary strong { font-size: 0.86rem; }
    .restriction-mechanism.is-dpni-workflow {
        min-height: 470px;
        grid-template-rows: auto minmax(17rem, 1fr) auto auto;
    }
    .rm-dpni-stage { grid-template-columns: 1fr; }
    .rm-dpni-track {
        padding: 0.35rem 0.4rem;
        grid-template-columns: minmax(7.5rem, 0.72fr) minmax(0, 1.28fr);
        grid-template-rows: 1fr auto;
    }
    .rm-dpni-track + .rm-dpni-track {
        border-top: 1px solid rgba(21, 25, 43, 0.11);
        border-left: 0;
    }
    .rm-dpni-track-label {
        padding-right: 0.5rem;
        text-align: left;
    }
    .rm-dpni-target { min-height: 7rem; }
    .rm-dpni-methylation-key,
    .rm-dpni-preserved-key {
        grid-column: 1 / -1;
    }
}